jueves, 5 de febrero de 2009

Filoviruses

Publicado por Maverick Panditas


Filoviruses: Un compendio de 40 años de Estudios Epidemiológicos, Clínicos y de Laboratorio
Filoviruses: A Compendium of 40 Years of Epidemiological, Clinical, and Laboratory Studies
Autor: Jens Kuhn
Idioma: Inglés
Número de páginas: 413
Materia: Biología
Año: 2008
Formato: PDF
ISBN: 3211206701



CONTENIDO:

4. INTRODUCTION
4.1. Viral hemorrhagic fevers
4.2. Filovirus taxonomy, evolution, and phylogeny.
4.3. Biosafety concerns in filovirus research
4.4. Biosecurity concerns in filovirus research.
5. HISTORY OF FILOVIRAL DISEASE OUTBREAKS
5.1. Lake Victoria marburgvirus
5.2. Zaire ebolavirus
5.3. Sudan ebolavirus.
5.4. Reston ebolavirus
5.5. C^ote d’Ivoire ebolavirus.
5.6. Speculations regarding the occurrence of additional filovirus infections
5.7. Conclusions
6. CLINICAL PRESENTATION OF FILOVIRAL DISEASE..
6.1. Lake Victoria marburgvirus infections
6.2. Zaire ebolavirus infections
6.3. Sudan ebolavirus infections.
6.4. Reston ebolavirus infections
6.5. Côte d’Ivoire ebolavirus infections
6.6. Conclusions
7. FILOVIRAL DISEASE PATHOLOGY
7.1. Marburgvirus disease pathology
7.2. Zaire ebolavirus disease pathology.
7.3. Sudan ebolavirus disease pathology
7.4. Reston ebolavirus disease pathology
7.5. C^ote d’Ivoire ebolavirus disease pathology.
7.6. Conclusions
8. GEOGRAPHIC DISTRIBUTION OF FILOVIRUSES: SEROLOGICAL SURVEYS
8.1. Belarus and Ukraine
8.2. Benin.
8.3. Botswana
8.4. Burkina Faso
8.5. Cameroon.
8.6. Central African Republic
8.7. Congo (Brazzaville).
8.8. C^ote d’Ivoire
8.9. Djibouti
8.10. Ethiopia
8.11. Gabon
8.12. Guinea.
8.13. Kenya
8.14. Liberia.
8.15. Madagascar.
8.16. Nigeria.
8.17. Panama
8.18. Philippines
8.19. Rhodesia/Zimbabwe
8.20. Senegal
8.21. Sierra Leone.
8.22. Sudan.
8.23. Togo
8.24. Uganda
8.25. Zaire/Democratic Republic of Congo
8.26. Other surveys
8.27. Conclusions
9. ECOLOGY OF FILOVIRUSES: SEARCH FOR RESERVOIRS
9.1. Filoviruses and their association with nonhuman primates
9.2. Bats as filovirus reservoirs
9.3. Other possible filovirus reservoirs
9.4. Conclusions
10. CULTIVATION OF FILOVIRUSES
10.1. Lake Victoria marburgvirus in cell cultures.
10.2. Ebolaviruses in cell cultures
11. MOLECULAR CHARACTERISTICS OF FILOVIRUSES
11.1. Ultrastructure
11.2. Filoviral genomes
11.3. Filoviral subgenomic mRNAs and their expression products
11.4. Cellular filovirus lifecycle.
11.5. Pathogenesis of filoviral disease
11.6. Conclusions
12. LABORATORY DIAGNOSIS OF FILOVIRAL DISEASE
12.1. Detection of filoviral RNA
12.2. Filovirus isolation
12.3. Detection of filoviral antigen.
12.4. Detection of specific antibodies to filoviruses
12.5. Immunohistochemistry
12.6. Electron microscopy
12.7. Outlook
13. OUTBREAK CONTAINMENT
13.1. Global containment
13.2. Outbreak control in Africa
13.3. Outbreak control in developed countries.
14. INACTIVATION OF FILOVIRUSES AND DISINFECTION PROTOCOLS
15. VACCINE DEVELOPMENT.
15.1. Inactivated filovirions and filovirus-like particles
15.2. DNA candidate vaccines.
15.3. Adenovirus candidate vaccines
15.4. Venezuelan equine encephalitis virus-based candidate vaccines
15.5. Vaccinia virus-based candidate vaccines
15.6. Picornavirus-based candidate vaccines
15.7. Vesiculovirus-based candidate vaccines.
15.8. Respirovirus-based candidate vaccines
15.9. Subunit candidate vaccines
15.10. Attenuated candidate vaccines
15.11. Other candidate vaccines
15.12. Conclusions
16. TREATMENT OF FILOVIRAL DISEASE
16.1. Supportive treatment
16.2. Mitigating filoviral disease by modifying host responses.
16.3. Filovirus-specific antivirals
16.4. Combinatorial treatment
17. APPENDIX: Members of the Filoviridae Study Group, ICTV.

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Filoviruses: A Compendium of 40 Years of Epidemiological, Clinical, and Laboratory Studies

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