domingo, 15 de marzo de 2009

Toxicología de los Compuestos Organfosforados y Carbamatos

Publicado por Maverick Panditas


Toxicology of Organophosphate and Carbamate Compounds
Autor: Ramesh C. Gupta
Idioma: Inglés
Número de páginas: 768
Materia: Salud Pública
Año: 2005
Formato: PDF
ISBN: 0120885239

Este texto de referencia proporciona la más completa cobertura de los compuestos anticolinesterásicos (organofosforados y carbamatos), que constituyen el mayor número de productos químicos que se utilizan principalmente como insecticidas en la agricultura, la industria y alrededores de casas y jardines. Algunos órganos fosforados (agentes neurotóxicos) se han utilizado en la guerra química y ataques terroristas, mientras que algunos otros órgano fosforados y carbamatos se han recomendado como agentes terapéuticos en medicina humana, así como en la medicina veterinaria. Muchos productos químicos de ambas clases son extremadamente tóxicos y poco selectivos, por lo que su uso accidental o involuntario sigue constituyendo una amenaza para la salud humana y animal, los sistemas acuáticos y la vida silvestre. Estos agentes anticolinestarásicos producen una variedad de efectos toxicológicos en órganos blanco como en aquellos que no lo son.

CONTENIDO:

SECTION I: USESABUSES& EPIDEMIOLOGY
Introduction
Classification and Uses of Organophosphates and Carbamates
Therapeutic Uses of Cholinesterase Inhibitors in Neurodegenerative Diseases
Coadministration of Memantine with Acetylcholinesterase Inhibitors: Preclinical and Clinical Evidence
Cholinesterase Inhibitors as Chemical Warfare Agents: Community Preparedness Guidelines
Organophosphates and the Gulf War Syndrome
The Bhopal Accident and Methyl Isocyanate Toxicity
Global Epidemiology of Organophosphate and Carbamate Poisonings

SECTION II: PHARMACOKINETICS & METABOLISM
Physiologically Based Pharmacokinetic Modeling of Organophosphorus and Carbamate Pesticides
O Metabolism of Organophosphorus and Carbamate Pesticides
Interspecies Variation in Toxicity of Cholinesterase Inhibitors

SECTION III: ESTERASESRECEPTORSMECHANISMS& TOLERANCE DEVELOPMENT
Structure and Function of Cholinesterases
Cholinesterase Pharmacogenetics
Methods for Measuring Cholinesterase Activities in Human Blood
Interactions of Organophosphorus and Carbamate Compounds with Cholinesterases
Structure Function and Regulation of Carboxylesterases
Noncholinesterase Mechanisms of Central and Peripheral Neurotoxicity: Muscarinic Receptors and Other Targets
Paraoxonase Polymorphisms and Toxicity of Organophosphates
Tolerance Development to Toxicity of Cholinesterase Inhibitors

SECTION IV: ORGAN TOXICITY
Central Nervous System Effects and Neurotoxicity
Developmental Neurotoxicity of Organophosphates: A Case Study of Chlorpyrifos
In Vitro Models for Testing Organophosphate-Induced Neurotoxicity and Remediation
Electrophysiological Mechanisms in Neurotoxicity of Organophosphates and Carbamates
Behavioral Toxicity of Cholinesterase Inhibitors
Peripheral Nervous System Effects and Delayed Neuropathy
Intermediate Syndrome in Organophosphate Poisoning
Cardiovascular Toxicity of Cholinesterase Inhibitors
Pulmonary Toxicity of Cholinesterase Inhibitors
Approaches to Defining and Evaluating the Inhalation Pharmacology and Toxicology Hazards of Anticholinesterases
Dermal Absorption Toxicity of Organophosphates and Carbamates
Local and Systemic Ophthalmic Pharmacology and Toxicology of Organophosphate and Carbamate Anticholinesterases
Reproductive Toxicity of Organophosphate and Carbamate Pesticides
Placental Toxicity of Organophosphate and Carbamate Pesticides
Endocrine Disruption by Organophosphate and Carbamate Pesticides
Organophosphates, Carbamates and the Immune System

SECTION V: NONSPECIFIC TOXIC EFFECTS
Oxidative Stress in Anticholinesterase-Induced Excitotoxicity
DNA Damage Gene Expression and Carcinogenesis by Organophosphates and Carbamates
Temperature Regulation in Experimental Mammals and Humans Exposed to Organophosphate and Carbamate Agents
Occupational Toxicology and Occupational Hygiene Aspects of Organophosphate and Carbamate Anticholinesterases with Particular Reference to Pesticides

SECTION VI: RISK ASSESSMENT & REGULATIONS
Public Health Impacts of Organophosphates and Carbamates
Cumulative Effects of Organophosphorus or Carbamate Pesticides
Federal Regulations and Risk Assessment of Organophosphate and Carbamate Pesticides
Regulatory Considerations in Developmental Neurotoxicity of Organophosphorus and Carbamate Pesticides
WHO/FAO Guidelines for Cholinesterase-Inhibiting Pesticide Residues in Food

SECTION VII: AQUATIC LIFE & WILDLIFE
Aquatic Toxicity of Carbamates and Organophosphates
Toxicity of Organophosphorus and Carbamate Insecticides Using Birds as Sentinels for Terrestrial Vertebrate Wildlife

SECTION VIII: ANALYTICAL & BIOMARKERS
Analysis of Organophosphate and Carbamate Pesticides and Anti cholinesterase Therapeutic Agents
Biomarkers of Organophosphate Exposure
SECTION IX: THERAPEUTIC MEASURES
Management of Organophosphorus Pesticide Poisoning

1 comentario:

Anónimo dijo...

excelente gracias

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