sábado, 31 de enero de 2009

Manual del Metabolismo de las Drogas

Publicado por Maverick Panditas


Handbook of Drug Metabolism
Autor: Paul G. Pearson (Editor), Larry C. Wienkers
Idioma: Inglés
Número de páginas: 616
Materia: Biología
Año: 2008
Formato: PDF
ISBN: 1420076477

CONTENIDO:

PART I: FUNDAMENTAL ASPECTS OF DRUG METABOLISM
1. The Evolution of Drug Metabolism Research
2. Pharmacokinetics of Drug Metabolites
3. Hepatic Architecture: Functional and Subcellular Correlates
4. The Cytochrome P450 Oxidative System
5. Transformation Enzymes: Oxidative; Non-P450
6. UDP-Glucuronosyltransferases
PART II: FACTORS WHICH AFFECT DRUG METABOLISM
7. Pharmacogenetics.
8. Inhibition of Drug Metabolizing Enzymes
9. The Ontogeny of Drug Metabolizing Enzymes/Pediatric Exclusivity
10. Sites of Extra Hepatic Metabolism, Part I: Lung
11. Sites of Extra Hepatic Metabolism, Part II: Gut
12. Sites of Extra Hepatic Metabolism, Part III: Kidney
13. Sites of Extra Hepatic Metabolism, Part IV: Brain
PART III: TECHNOLOGIES TO STUDY DRUG METABOLISM
14. LC-MS Analysis in Drug Metabolism Studies
15. The Practice of NMR Spectroscopy in Drug Metabolism Studies
16. Applications of Recombinant and Purified Human Drug-Metabolizing Enzymes: An Industrial Perspective
17. In Vitro Metabolism: Subcellular Fractions
18. In Vitro Metabolism: Hepatocytes
19. Drug Interaction Studies in the Drug Development Process: Studies In Vitro
20. Enzyme Induction Studies in Drug Discovery & Development
21. Experimental Characterization of Cytochrome P450 Mechanism Based Inhibition
PART IV: APPLICATIONS OF METABOLISM STUDIES IN DRUG DISCOVERY AND DEVELOPMENT
22. Clinical Drug Metabolism
23. Minimizing Metabolic Activation in Drug Discovery
24. Kinetic Differences between Generated and Preformed Metabolites: A Dilemma in Risk Assessment
25. The Use of Transgenic Animals to Study Drug Metabolism
26. Preclinical Pharmacokinetic Models for Drug Discovery and Development


No hay comentarios:

Publicar un comentario